A trifunctional self-immolative spacer enables drug release with two non-sequential enzymatic cleavages
نویسندگان
چکیده
The enzymatic dephosphorylation of a self-immolative spacer accelerates cargo release and acts as an additional independent trigger in protease-sensitive prodrugs.
منابع مشابه
Modifications of the Self-Immolative Spacer PABOH in Antibody Drug Conjugates
........................................................................................................................................... i Acknowledgements ......................................................................................................................... ii Table of
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ژورنال
عنوان ژورنال: Chemical Communications
سال: 2021
ISSN: ['1359-7345', '1364-548X']
DOI: https://doi.org/10.1039/d1cc02895b